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KMID : 0882420110810010082
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Korean Journal of Medicine
2011 Volume.81 No. 1 p.82 ~ p.88
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Comparison of the Urine Protein to Creatinine Ratio with 24-Hour Urinary Protein Amounts in Patients with Kidney Transplants
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Kim Su-Jin
Choi An-Sook
Lee Jin-Ho
Yu Seong-Min
Oh Joon-Seok
Kim Sung-Min
Shin Yong-Hun
Kim Joong-Kyung
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Abstract
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Background/Aims: Many studies have reported the correlation between the spot urine protein to creatinine (P/C) ratio and 24-hour urinary protein amounts in patients with glomerulonephritis. This correlation has also been reported in Western patients with kidney transplants, but no prior study has reported on this association in Eastern populations. We compare the correlation between the spot urine P/C ratio and 24-hour urinary protein amounts and the associating factors in Korean patients with kidney transplants.
Methods: The study included 66 patients with kidney transplants from our hospital. The subjects had urine samples evaluated between January 2005 and July 2010. We compared 24-hour urinary protein amounts with a spot urine P/C ratio collected in the morning and analyzed the factors affecting the correlation in each group.
Results: The 24-hour urinary protein amounts were 1.31 ± 1.69 g/day and the spot urine P/C ratio was 1.29 ± 1.70 in all subjects. A strong positive linear correlation was observed between the 24-hour urinary protein amounts and the spot urine P/C ratio (r = 0.95). The primary factor affecting accurate quantitation of proteinuria using the spot urine P/C ratio was gender (p = 0.003). The spot urine P/C ratio and the 24-hour urinary protein levels were 1.05 ± 1.51 and 1.26 ± 1.68 g/day in males (p = 0.005) and 1.57 ± 1.88 and 1.36 ± 1.72 g/day in females (p = 0.047), respectively.
Conclusions : We determined that the spot urine P/C ratio provides an accurate estimate of 24-hour urinary protein levels in Korean patients with kidney transplants.
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KEYWORD
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Proteinuria, Kidney transplantation
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